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Title: The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid β Load in Early Alzheimer's Disease
Authors: Jorge, Lília
Canário, Nádia
Martins, Ricardo 
Santiago, Beatriz 
Santana, Isabel
Quental, Hugo
Ambrósio, Francisco
Bernardes, Rui 
Castelo-Branco, Miguel 
Issue Date: 2020
Serial title, monograph or event: Neural Plasticity
Volume: 2020
Abstract: The retina may serve as putative window into neuropathology of synaptic loss in Alzheimer's disease (AD). Here, we investigated synapse-rich layers versus layers composed by nuclei/cell bodies in an early stage of AD. In addition, we examined the associations between retinal changes and molecular and structural markers of cortical damage. We recruited 20 AD patients and 17 healthy controls (HC). Combining optical coherence tomography (OCT), magnetic resonance (MR), and positron emission tomography (PET) imaging, we measured retinal and primary visual cortex (V1) thicknesses, along with V1 amyloid β (Aβ) retention ([11C]-PiB PET tracer) and neuroinflammation ([11C]-PK11195 PET tracer). We found that V1 showed increased amyloid-binding potential, in the absence of neuroinflammation. Although thickness changes were still absent, we identified a positive association between the synapse-rich inner plexiform layer (IPL) and V1 in AD. This retinocortical interplay might reflect changes in synaptic function resulting from Aβ deposition, contributing to early visual loss.
ISSN: 2090-5904
DOI: 10.1155/2020/8826087
Rights: openAccess
Appears in Collections:I&D ICNAS - Artigos em Revistas Internacionais

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