Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/91066
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jorge, Andreia | - |
dc.contributor.author | Pais, Alberto | - |
dc.contributor.author | Vitorino, Carla | - |
dc.date.accessioned | 2020-09-18T12:03:40Z | - |
dc.date.available | 2020-09-18T12:03:40Z | - |
dc.date.issued | 2020 | - |
dc.identifier.isbn | 978-1-4939-9797-8 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/91066 | - |
dc.description.abstract | Efficient intracellular delivery of small-interfering ribonucleic acid (siRNA) to the target organ or tissues in the body is assumed as the main hurdle for a widespread use of siRNAs in the clinics. Solid lipid-based nanoparticles (SLNs) and derivatives can potentially fit this purpose by enabling to overcome the extracellular and intracellular physiological barriers affecting the delivery. For that, rational formulations and rational process designs are needed. This chapter addresses a comprehensive description and critical appraisal of the main production methods of this particular type of lipid nanoparticles and the leading strategies to prompt a targeted delivery of siRNA. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | POCI-01-0145-FEDER- 016648 | pt |
dc.relation | PEst- UID/NEU/04539/2013 | pt |
dc.relation | POCI-01- 0145-FEDER-007440 | pt |
dc.relation | CENTRO-01-0145-FEDER-030752 | pt |
dc.relation | PEst- OE/QUI/UI0313/2014 | pt |
dc.relation | POCI-01-0145-FEDER-007630 | pt |
dc.relation | SFRH/BPD/104544/2014 | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | RNA interference | pt |
dc.subject | Solid lipid-based nanoparticles | pt |
dc.subject | Targeting | pt |
dc.subject | siRNA delivery | pt |
dc.subject | Temperature-based methods | pt |
dc.subject | Solvent-based methods | pt |
dc.title | Targeted siRNA Delivery Using Lipid Nanoparticles | pt |
dc.type | book | pt |
degois.publication.firstPage | 259 | pt |
degois.publication.lastPage | 283 | pt |
degois.publication.title | Drug Delivery Systems | pt |
dc.relation.publisherversion | https://link.springer.com/protocol/10.1007%2F978-1-4939-9798-5_14 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1007/978-1-4939-9798-5_14 | pt |
degois.publication.volume | 2059 | pt |
dc.date.embargo | 2022-11-16 | * |
uc.date.periodoEmbargo | 1050 | pt |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | book | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_2f33 | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-6725-6460 | - |
crisitem.author.orcid | 0000-0003-3424-548X | - |
Appears in Collections: | I&D CQC - Livros e capítulos de livros |
Files in This Item:
File | Description | Size | Format | |
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Chapter_14.pdf | 293.95 kB | Adobe PDF | View/Open |
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