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Title: Porous poly(ε-caprolactone) implants: A novel strategy for efficient intraocular drug delivery
Authors: Boia, Raquel 
Dias, Paulo A. N.
Martins, Joana M.
Galindo-Romero, Caridad
Aires, Inês D. 
Vidal-Sanz, Manuel
Agudo-Barriuso, Marta
Sousa, Hermínio C. de 
Ambrósio, António Francisco 
Braga, Mara E. M. 
Santiago, Ana Raquel 
Keywords: Biodegradable porous implants; Intraocular drug delivery; Poly (ε-caprolactone); Retina; Safety; Supercritical carbon dioxide foaming/mixing method
Issue Date: 9-Nov-2019
Publisher: Elsevier {BV}
Project: FCT, Portugal 
Centro2020 Regional Operational Programme 
Serial title, monograph or event: Journal of Contolled Release
Volume: 316
Place of publication or event: The Boulevard Langford Lane Kidlington Oxford OX5 1GB United Kingdom
Abstract: This work reports the development of porous poly (ε-caprolactone) (PCL)-based intraocular implants, prepared by green supercritical carbon dioxide (scCO2) foaming/mixing method (SFM), to produce implants that degrade faster than typical slow-degrading PCL-based implants. The higher porosities and surface areas of these implants led to faster degradation rates at in vitro accelerated alkaline conditions than low porosity/surface area implants prepared by hot melting processing. These porous implants also presented distinct (faster) release rates of a test-drug (dexamethasone). Additionally, these porous devices did not cause cell death and did not reduce the number of neurons, indicating that are not toxic to retinal cells. We further explored the impact of PCL-based implant to the retina by in vivo evaluation and histological analysis. Implants were surgically inserted in the vitreous of Wistar rats, and their presence did not change the function, structure and anatomy of the retina. These devices demonstrated a good intraocular tolerance, further confirming their viability for prolonged drug delivery applications. Further comprehensive studies based on this promising preliminary assessment and proof-of-concept could enable its future translation to clinical protective strategies for retinal diseases.
ISSN: 01683659
DOI: 10.1016/j.jconrel.2019.09.023
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais

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