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Title: Advanced Mechanochemistry Device for Sustainable Synthetic Processes
Authors: Gomes, Carla
Vinagreiro, Carolina dos Santos 
Damas, Liliana Reis 
Aquino, Gilberto Lucio Benedito 
Quaresma, Joana Filipa Pires d'Oliveira 
Chaves, Cristina Manuel Monteiro 
Pimenta, João
Campos, José L. S. de A. 
Pereira, Maria Miguéns 
Piñeiro Gomez, Marta 
Issue Date: 19-May-2020
Publisher: ACS Publications
Project: UIDB/00313/ 2020 
Volume: 5
Issue: 19
Abstract: Mechanochemistry is an alternative for sustainable solvent-free processes that has taken the big step to become, in the near future, a useful synthetic method for academia and the fine chemical industry. The apparatus available, based on ball milling systems possessing several optimizable variables, requires too many control and optimization experiments to ensure reproducibility, which has limited its widespread utilization so far. Herein, we describe the development of an automatic mechanochemical single-screw device consisting of an electrical motor, a drill, and a drill chamber. The applicability and versatility of the new device are demonstrated by the implementation of di- and multicomponent chemical reactions with high reproducibility, using mechanical action exclusively. As examples, chalcones, dihydropyrimidinones, dihydropyrimidinethiones, pyrazoline, and porphyrins, were synthesized with high yields. The unprecedented sustainability is demonstrated by comparison of EcoScale and E-factor values of these processes with those previously described in the literature.
ISSN: 2470-1343
DOI: 10.1021/acsomega.0c00521
Rights: openAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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