Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/90775
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dc.contributor.authorGomes, Carla-
dc.contributor.authorVinagreiro, Carolina dos Santos-
dc.contributor.authorDamas, Liliana Reis-
dc.contributor.authorAquino, Gilberto Lucio Benedito-
dc.contributor.authorQuaresma, Joana Filipa Pires d'Oliveira-
dc.contributor.authorChaves, Cristina Manuel Monteiro-
dc.contributor.authorPimenta, João-
dc.contributor.authorCampos, José L. S. de A.-
dc.contributor.authorPereira, Maria Miguéns-
dc.contributor.authorPiñeiro Gomez, Marta-
dc.date.accessioned2020-09-04T09:49:45Z-
dc.date.available2020-09-04T09:49:45Z-
dc.date.issued2020-05-19-
dc.identifier.issn2470-1343pt
dc.identifier.urihttp://hdl.handle.net/10316/90775-
dc.description.abstractMechanochemistry is an alternative for sustainable solvent-free processes that has taken the big step to become, in the near future, a useful synthetic method for academia and the fine chemical industry. The apparatus available, based on ball milling systems possessing several optimizable variables, requires too many control and optimization experiments to ensure reproducibility, which has limited its widespread utilization so far. Herein, we describe the development of an automatic mechanochemical single-screw device consisting of an electrical motor, a drill, and a drill chamber. The applicability and versatility of the new device are demonstrated by the implementation of di- and multicomponent chemical reactions with high reproducibility, using mechanical action exclusively. As examples, chalcones, dihydropyrimidinones, dihydropyrimidinethiones, pyrazoline, and porphyrins, were synthesized with high yields. The unprecedented sustainability is demonstrated by comparison of EcoScale and E-factor values of these processes with those previously described in the literature.pt
dc.language.isoengpt
dc.publisherACS Publicationspt
dc.relationUIDB/00313/ 2020pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.titleAdvanced Mechanochemistry Device for Sustainable Synthetic Processespt
dc.typearticle-
degois.publication.firstPage10868pt
degois.publication.lastPage10877pt
degois.publication.issue19pt
dc.relation.publisherversionhttps://pubs.acs.org/doi/pdf/10.1021/acsomega.0c00521pt
dc.peerreviewedyespt
dc.identifier.doi10.1021/acsomega.0c00521pt
degois.publication.volume5pt
dc.date.embargo2020-05-19*
uc.date.periodoEmbargo0pt
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitLAETA - Associated Laboratory for Energy, Transports and Aeronautics-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-3848-5918-
crisitem.author.orcid0000-0002-6067-3069-
crisitem.author.orcid0000-0003-4958-7677-
crisitem.author.orcid0000-0002-7460-3758-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
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