Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/88878
Title: Incorporating the Local Biological Effect of Dose Per Fraction in IMRT Inverse Optimization
Authors: da Costa Ferreira, Brígida
Mavroidis, Panayiotis 
Dias, Joana
Rocha, Humberto 
Keywords: Radiation therapy; IMRT optimization
Issue Date: 2019
Publisher: Springer
Serial title, monograph or event: IFMBE
Volume: 68
Abstract: In intensity modulated radiation therapy (IMRT), the dose in each voxel of the organs at risk (OAR) can be strongly reduced compared to conformal radiation therapy (RT). Due to the sensitivity of late side-effects to fraction size, a smaller dose per fraction in the normal tissues represent an increased tolerance to RT. This expected reduction in biological effect may then be used as an additional degree of freedom during IMRT optimization. In this study, the comparison between plans optimized with and without a voxel-based fractionation correction was made.
URI: http://hdl.handle.net/10316/88878
ISBN: 978-981-10-9022-6
DOI: 10.1007/978-981-10-9023-3_74
Rights: openAccess
Appears in Collections:I&D CeBER - Livros e Capítulos de Livros

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