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https://hdl.handle.net/10316/88878
Title: | Incorporating the Local Biological Effect of Dose Per Fraction in IMRT Inverse Optimization | Authors: | Ferreira, Brígida da Costa Mavroidis, Panayiotis Dias, Joana Rocha, Humberto |
Keywords: | Radiation therapy; IMRT optimization | Issue Date: | 2019 | Publisher: | Springer | Serial title, monograph or event: | IFMBE | Volume: | 68 | Abstract: | In intensity modulated radiation therapy (IMRT), the dose in each voxel of the organs at risk (OAR) can be strongly reduced compared to conformal radiation therapy (RT). Due to the sensitivity of late side-effects to fraction size, a smaller dose per fraction in the normal tissues represent an increased tolerance to RT. This expected reduction in biological effect may then be used as an additional degree of freedom during IMRT optimization. In this study, the comparison between plans optimized with and without a voxel-based fractionation correction was made. | URI: | https://hdl.handle.net/10316/88878 | ISBN: | 978-981-10-9022-6 | DOI: | 10.1007/978-981-10-9023-3_74 | Rights: | openAccess |
Appears in Collections: | I&D CeBER - Livros e Capítulos de Livros |
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File | Description | Size | Format | |
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Ferreira_2018.pdf | Incorporating the Local Biological Effect of Dose Per Fraction in IMRT Inverse Optimization | 368.27 kB | Adobe PDF | View/Open |
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