Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/87807
Title: | Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases | Authors: | Gomes, Pedro Leal, Helena Mendes, Alexandrina F. Reis, Flávio Cavadas, Cláudia |
Keywords: | age-related diseases; cardiometabolic diseases; genetic manipulations; neurodegeneration; pharmacological modulators; sirtuins | Issue Date: | 5-Nov-2019 | Serial title, monograph or event: | Trends Pharmacolological Sciences | Abstract: | Sirtuins (SIRT1-7), a class of NAD+-dependent deacylases, are central regulators of metabolic homeostasis and stress responses. While numerous salutary effects associated with sirtuin activation, especially SIRT1, are well documented, other reports show health benefits resulting from sirtuin inhibition. Furthermore, conflicting findings have been obtained regarding the pathophysiological role of specific sirtuin isoforms, suggesting that sirtuins act as 'double-edged swords'. Here, we provide an integrated overview of the different findings on the role of mammalian sirtuins in neurodegenerative and cardiometabolic disorders and attempt to dissect the reasons behind these different effects. Finally, we discuss how addressing these obstacles may provide a better understanding of the complex sirtuin biology and improve the likelihood of identifying effective and selective drug targets for a variety of human disorders. | URI: | https://hdl.handle.net/10316/87807 | ISSN: | 01656147 | DOI: | 10.1016/j.tips.2019.09.003 | Rights: | embargoedAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | Login |
---|---|---|---|---|
1-s2.0-S0165614719302147-main.pdf | 1.56 MB | Adobe PDF | Embargo Access Request a copy |
SCOPUSTM
Citations
23
checked on May 1, 2023
WEB OF SCIENCETM
Citations
50
24
checked on Oct 2, 2024
Page view(s)
268
checked on Oct 1, 2024
Download(s)
67
checked on Oct 1, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.