Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8340
Title: Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability
Authors: Fernandes, Maria A. S. 
Santos, Maria S. 
Moreno, António J. M. 
Duburs, Gunars 
Oliveira, Catarina R. 
Vicente, Joaquim A. F. 
Issue Date: 2004
Citation: Journal of Biochemical and Molecular Toxicology. 18:3 (2004) 162-169
Abstract: The interference of glibenclamide, an antidiabetic sulfonylurea, with mitochondrial bioenergetics was assessed on mitochondrial ion fluxes (H+, K+, and Cl-) by passive osmotic swelling of rat liver mitochondria in K-acetate, KNO3, and KCl media, by O2 consumption, and by mitochondrial transmembrane potential (Deltapsi). Glibenclamide did not permeabilize the inner mitochondrial membrane to H+, but induced permeabilization to Cl- by opening the inner mitochondrial anion channel (IMAC). Cl- influx induced by glibenclamide facilitates K+ entry into mitochondria, thus promoting a net Cl-/K+ cotransport, Deltapsi dissipation, and stimulation of state 4 respiration rate. It was concluded that glibenclamide interferes with mitochondrial bioenergetics of rat liver by permeabilizing the inner mitochondrial membrane to Cl- and promoting a net Cl-/K+ cotransport inside mitochondria, without significant changes on membrane permeabilization to H+. © 2004 Wiley Periodicals, Inc. J Biochem Mol Toxicol 18:162-169, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20022
URI: http://hdl.handle.net/10316/8340
DOI: 10.1002/jbt.20022
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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