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https://hdl.handle.net/10316/8340
Title: | Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability | Authors: | Fernandes, Maria A. S. Santos, Maria S. Moreno, António J. M. Duburs, Gunars Oliveira, Catarina R. Vicente, Joaquim A. F. |
Issue Date: | 2004 | Citation: | Journal of Biochemical and Molecular Toxicology. 18:3 (2004) 162-169 | Abstract: | The interference of glibenclamide, an antidiabetic sulfonylurea, with mitochondrial bioenergetics was assessed on mitochondrial ion fluxes (H+, K+, and Cl-) by passive osmotic swelling of rat liver mitochondria in K-acetate, KNO3, and KCl media, by O2 consumption, and by mitochondrial transmembrane potential (Deltapsi). Glibenclamide did not permeabilize the inner mitochondrial membrane to H+, but induced permeabilization to Cl- by opening the inner mitochondrial anion channel (IMAC). Cl- influx induced by glibenclamide facilitates K+ entry into mitochondria, thus promoting a net Cl-/K+ cotransport, Deltapsi dissipation, and stimulation of state 4 respiration rate. It was concluded that glibenclamide interferes with mitochondrial bioenergetics of rat liver by permeabilizing the inner mitochondrial membrane to Cl- and promoting a net Cl-/K+ cotransport inside mitochondria, without significant changes on membrane permeabilization to H+. © 2004 Wiley Periodicals, Inc. J Biochem Mol Toxicol 18:162-169, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20022 | URI: | https://hdl.handle.net/10316/8340 | DOI: | 10.1002/jbt.20022 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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