Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/8340
DC Field | Value | Language |
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dc.contributor.author | Fernandes, Maria A. S. | - |
dc.contributor.author | Santos, Maria S. | - |
dc.contributor.author | Moreno, António J. M. | - |
dc.contributor.author | Duburs, Gunars | - |
dc.contributor.author | Oliveira, Catarina R. | - |
dc.contributor.author | Vicente, Joaquim A. F. | - |
dc.date.accessioned | 2009-02-09T14:33:24Z | - |
dc.date.available | 2009-02-09T14:33:24Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Journal of Biochemical and Molecular Toxicology. 18:3 (2004) 162-169 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/8340 | - |
dc.description.abstract | The interference of glibenclamide, an antidiabetic sulfonylurea, with mitochondrial bioenergetics was assessed on mitochondrial ion fluxes (H+, K+, and Cl-) by passive osmotic swelling of rat liver mitochondria in K-acetate, KNO3, and KCl media, by O2 consumption, and by mitochondrial transmembrane potential (Deltapsi). Glibenclamide did not permeabilize the inner mitochondrial membrane to H+, but induced permeabilization to Cl- by opening the inner mitochondrial anion channel (IMAC). Cl- influx induced by glibenclamide facilitates K+ entry into mitochondria, thus promoting a net Cl-/K+ cotransport, Deltapsi dissipation, and stimulation of state 4 respiration rate. It was concluded that glibenclamide interferes with mitochondrial bioenergetics of rat liver by permeabilizing the inner mitochondrial membrane to Cl- and promoting a net Cl-/K+ cotransport inside mitochondria, without significant changes on membrane permeabilization to H+. © 2004 Wiley Periodicals, Inc. J Biochem Mol Toxicol 18:162-169, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20022 | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1002/jbt.20022 | en_US |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | MARE - Marine and Environmental Sciences Centre | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-6881-9392 | - |
crisitem.author.orcid | 0000-0003-3575-7604 | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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