Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8305
Title: Electrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrode
Authors: Brett, Ana Maria Oliveira 
Serrano, Sílvia H. P. 
Macedo, Tice A. 
Raimundo, Dulce 
Marques, M. Helena 
La-Scalea, Mauro A. 
Issue Date: 1996
Citation: Electroanalysis. 8:11 (1996) 992-995
Abstract: An electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially with adenine rather than guanine groups in the DNA and they can contribute to clarifying the mechanisms of interaction of platinum anticancer drugs with DNA. The pharmacokinetics corresponding to the administration of the drug was followed electrochemically and the detection limit in serum samples was 5.7 × 10 -6M. Due to a similar mechanism of reaction with DNA other platinum anticancer drugs can be determined by this method.
URI: http://hdl.handle.net/10316/8305
DOI: 10.1002/elan.1140081104
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
obra.pdf415.16 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

97
checked on Feb 18, 2020

Page view(s)

234
checked on Apr 1, 2020

Download(s)

98
checked on Apr 1, 2020

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.