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https://hdl.handle.net/10316/8274
Title: | Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec | Authors: | Diculescu, Victor Constantin Vivan, Marilene Brett, Ana Maria Oliveira |
Issue Date: | 2006 | Citation: | Electroanalysis. 18:18 (2006) 1800-1807 | Abstract: | The electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH-dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, Pglivec, which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of Pglivec at the GCE surface yields a compact monolayer that inhibits further oxidation of glivec. The electrochemical reduction is a simple pH dependent irreversible process involving the transfer of 2 electrons and 2 protons and occurs with the formation of a nonelectroactive product. The diffusion coefficient of glivec was calculated to be DO=7.35×10-6 cm2 s-1 in pH 4.5 0.1 M acetate buffer. | URI: | https://hdl.handle.net/10316/8274 | DOI: | 10.1002/elan.200603591 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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