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https://hdl.handle.net/10316/8106
Title: | Interactions Between Cyclodextrins and TmIII Chelates of Polyazamacrocycles as Studied by NMR in Aqueous Solution | Authors: | Zitha-Bovens, Emrin Bekkum, Herman van Peters, Joop A. Geraldes, Carlos F. G. C. |
Issue Date: | 1999 | Citation: | European Journal of Inorganic Chemistry. 1999:2 (1999) 287-293 | Abstract: | The interactions between α-, β-, and γ-CD and the TmIII chelates of the macrocyclic polyaminopolycarboxylates DOTA and NOTA were studied with the use of 1H- and 13C-NMR shift and relaxation rate measurements. Interactions were only observed between Tm(DOTA)- and γ-CD. The structure and the stability of the concerning supramolecular structures was elucidated by fitting of the NMR titration curves to a theoretical model. It appears that an inclusion compound is formed, where the hydrophobic macrocyclic part of the chelate sits in the γ-CD cavity. This inclusion compound binds a second Tm(DOTA)- molecule at the outside lower rim of the CD cone. The binding occurs probably via hydrogen bonds between non-chelated carboxylate oxygen atoms of the concerning Tm(DOTA)- and CH2OH groups of the γ-CD molecule, which are in a favorable position due to opening of the γ-CD cone angle as a result of the inclusion of the first γ-CD. | URI: | https://hdl.handle.net/10316/8106 | DOI: | 10.1002/(SICI)1099-0682(19990202)1999:2<287::AID-EJIC287>3.0.CO;2-W | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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