Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7900
Title: Stimulation of Immunoreactive Insulin Release by Glucose in Rat Brain Synaptosomes
Authors: Santos, Maria 
Pereira, Emilia 
Carvaho, Arsélio 
Issue Date: 1999
Citation: Neurochemical Research. 24:1 (1999) 33-36
Abstract: The effect of glucose on the release of immunoreactive insulin (IRI) in synaptosomes isolated from rat brain was studied. In the absence of glucose synaptosomes release about 4% (0.77 µIU/mg protein) of total content. Glucose increases significantly the IRI released by synaptosomes. Addition of the glycolytic inhibitor iodoacetic acid (IAA), decreased the glucose-induced release of IRI by about 50%, suggesting that glucose metabolism is involved. The observation that glucose provides a concentration related signal for IRI release indicates that this synaptosomal preparation may be useful as a model for research on the mechanism of insulin release in brain.
URI: http://hdl.handle.net/10316/7900
DOI: 10.1023/A:1020971812098
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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