Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/7900
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santos, Maria | - |
dc.contributor.author | Pereira, Emilia | - |
dc.contributor.author | Carvaho, Arsélio | - |
dc.date.accessioned | 2009-02-17T10:37:22Z | - |
dc.date.available | 2009-02-17T10:37:22Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Neurochemical Research. 24:1 (1999) 33-36 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/7900 | - |
dc.description.abstract | The effect of glucose on the release of immunoreactive insulin (IRI) in synaptosomes isolated from rat brain was studied. In the absence of glucose synaptosomes release about 4% (0.77 µIU/mg protein) of total content. Glucose increases significantly the IRI released by synaptosomes. Addition of the glycolytic inhibitor iodoacetic acid (IAA), decreased the glucose-induced release of IRI by about 50%, suggesting that glucose metabolism is involved. The observation that glucose provides a concentration related signal for IRI release indicates that this synaptosomal preparation may be useful as a model for research on the mechanism of insulin release in brain. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Stimulation of Immunoreactive Insulin Release by Glucose in Rat Brain Synaptosomes | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1023/A:1020971812098 | en_US |
uc.controloAutoridade | Sim | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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