Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7876
Title: Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease
Authors: Castellani, Rudy 
Moreira, Paula 
Liu, Gang 
Dobson, Jon 
Perry, George 
Smith, Mark 
Zhu, Xiongwei 
Issue Date: 2007
Publisher: Springer Netherlands
Citation: Neurochemical Research. 32:10 (2007) 1640-1645
Abstract: Abstract Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson’s disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD.
URI: http://hdl.handle.net/10316/7876
DOI: 10.1007/s11064-007-9360-7
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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