Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5769
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santos, Helton | - |
dc.contributor.author | Veiga, Francisco | - |
dc.contributor.author | Pina, M. Eugénia | - |
dc.contributor.author | Sousa, João José | - |
dc.date.accessioned | 2008-09-26T17:41:26Z | - |
dc.date.available | 2008-09-26T17:41:26Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | European Journal of Pharmaceutical Sciences. 21:2-3 (2004) 271-281 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/5769 | - |
dc.description.abstract | Compaction and compression of xanthan gum (XG) pellets were evaluated and drug release from tablets made of pellets was characterised. Three formulations were prepared by extrusion-spheronisation and included, among other excipients, diclofenac sodium (Dic Na), at 10% (w/w); xanthan gum, at 16% (w/w); and one of three different fillers (lactose monohydrated (LAC), tribasic calcium phosphate (TCP) and [beta]-cyclodextrin ([beta]-CD)), at 16% (w/w). Five hundred milligrams of pellets (fraction 1000-1400 [mu]m) were compacted in a single punch press at maximum punch pressure of 125 MPa using flat-faced punches (diameter of 1.00 cm). Physical properties of pellets and tablets were analysed. Dissolution was performed according to the USP paddle method. Pellets showed close compressibility degrees (49.27% LAC; 51.32% TCP; and 50.48% [beta]-CD) but densified differently (3.57% LAC; 14.84% TCP; 3.26% [beta]-CD). Permanent deformation and densification were the relevant mechanisms of compression. Fragmentation was regarded as non-existent. The release behaviour of tablets made of pellets comprising LAC or [beta]-CD was anomalous having diffusional exponent (n) values of 0.706 and 0.625, respectively. Drug diffusion and erosion were competing mechanisms of drug release from those tablets. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6T25-4B8BXPN-B/1/be51e8b55c37493496f79b0f4ae15cc2 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Pellets | en_US |
dc.subject | Extrusion-spheronisation | en_US |
dc.subject | Xanthan gum | en_US |
dc.subject | Compaction | en_US |
dc.subject | Compression | en_US |
dc.subject | Drug release | en_US |
dc.subject | Diffusion | en_US |
dc.subject | Erosion | en_US |
dc.title | Compaction, compression and drug release characteristics of xanthan gum pellets of different compositions | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.7897/2230-8407.07437 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-1041-0068 | - |
crisitem.author.orcid | 0000-0003-0189-1370 | - |
crisitem.author.orcid | 0000-0001-9718-8035 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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filec4b69a9d4aef4d31bf017832642f446e.pdf | 399.19 kB | Adobe PDF | View/Open |
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