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https://hdl.handle.net/10316/5769
Título: | Compaction, compression and drug release characteristics of xanthan gum pellets of different compositions | Autor: | Santos, Helton Veiga, Francisco Pina, M. Eugénia Sousa, João José |
Palavras-chave: | Pellets; Extrusion-spheronisation; Xanthan gum; Compaction; Compression; Drug release; Diffusion; Erosion | Data: | 2004 | Citação: | European Journal of Pharmaceutical Sciences. 21:2-3 (2004) 271-281 | Resumo: | Compaction and compression of xanthan gum (XG) pellets were evaluated and drug release from tablets made of pellets was characterised. Three formulations were prepared by extrusion-spheronisation and included, among other excipients, diclofenac sodium (Dic Na), at 10% (w/w); xanthan gum, at 16% (w/w); and one of three different fillers (lactose monohydrated (LAC), tribasic calcium phosphate (TCP) and [beta]-cyclodextrin ([beta]-CD)), at 16% (w/w). Five hundred milligrams of pellets (fraction 1000-1400 [mu]m) were compacted in a single punch press at maximum punch pressure of 125 MPa using flat-faced punches (diameter of 1.00 cm). Physical properties of pellets and tablets were analysed. Dissolution was performed according to the USP paddle method. Pellets showed close compressibility degrees (49.27% LAC; 51.32% TCP; and 50.48% [beta]-CD) but densified differently (3.57% LAC; 14.84% TCP; 3.26% [beta]-CD). Permanent deformation and densification were the relevant mechanisms of compression. Fragmentation was regarded as non-existent. The release behaviour of tablets made of pellets comprising LAC or [beta]-CD was anomalous having diffusional exponent (n) values of 0.706 and 0.625, respectively. Drug diffusion and erosion were competing mechanisms of drug release from those tablets. | URI: | https://hdl.handle.net/10316/5769 | DOI: | 10.7897/2230-8407.07437 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
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filec4b69a9d4aef4d31bf017832642f446e.pdf | 399.19 kB | Adobe PDF | Ver/Abrir |
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