Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/5743
Título: | Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation | Autor: | Silva, Catarina M. Ribeiro, António J. Ferreira, Domingos Veiga, Francisco |
Palavras-chave: | Alginate microspheres; Chitosan; Insulin release; Internal gelation; Anionic polyelectrolytes | Data: | 2006 | Citação: | European Journal of Pharmaceutical Sciences. 29:2 (2006) 148-159 | Resumo: | Insulin-loaded alginate microspheres prepared by emulsification/internal gelation were reinforced by blending with polyanionic additive polymers and/or chitosan-coating in order to increase the protection of insulin at simulated gastric pH and obtain a sustained release at simulated intestinal pH. Polyanionic additive polymers blended with alginate were cellulose acetate phtalate (CAP), Eudragit® L100 (EL100), sodium carboxymethylcellulose (CMC), polyphosphate (PP), dextran sulfate (DS) and cellulose sulfate (CS). Chitosan-coating was applied by using a one-stage procedure. The influence of additive polymers and chitosan-coating on the size distribution of microspheres, encapsulation efficiency and release profile of insulin in simulated gastrointestinal pH conditions was studied. The mean diameter of blended microspheres ranged from 65 to 106 [mu]m and encapsulation efficiency of insulin varied from 14 to 100%, reaching a maximum value when CS and DS were incorporated in the alginate matrix. Insulin release, at pH 1.2, was almost prevented by the incorporation of PP, DS and CS. When uncoated microspheres were transferred to pH 6.8, a fast dissolution occurred, independently of the additive polymer blended with alginate, and insulin was completely released. Increasing the additive polymer concentration in the alginate matrix and/or chitosan-coating the blended alginate microspheres did not promote a sustained release of insulin from microspheres at pH 6.8. | URI: | https://hdl.handle.net/10316/5743 | DOI: | 10.1016/j.ejps.2006.06.008 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
filef9ca2826cbcd4edc86107fdf2e94a24f.pdf | 927.57 kB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
102
Visto em 11/nov/2022
Citações WEB OF SCIENCETM
89
Visto em 2/mai/2023
Visualizações de página 50
602
Visto em 8/out/2024
Downloads 20
1.501
Visto em 8/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.