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https://hdl.handle.net/10316/5433
Title: | Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore | Authors: | Oliveira, Paulo J. Coxito, Pedro M. Rolo, Anabela P. Santos, Dario L. Palmeira, Carlos M. Moreno, António J. M. |
Issue Date: | 2001 | Citation: | European Journal of Pharmacology. 412:3 (2001) 231-237 | Abstract: | The mitochondrial permeability transition is a widely studied, but poorly understood, phenomenon in mitochondrial bioenergetics. It has been recognised that this phenomenon is related to the opening of a protein pore in the inner mitochondrial membrane, and that opening of this pore is the cause of some forms of mitochondrial dysfunction. In this work, we propose that carvedilol, a multi-role cardioprotective compound, may act as an inhibitor of the high-conductance state of the mitochondrial permeability transition pore, a conclusion supported by the finding that carvedilol provides differential protection against mitochondrial swelling in sucrose and KCl-based media, and that it is unable to protect against calcium-induced depolarisation of the mitochondrial membrane. We also show that carvedilol inhibits the oxidation of mitochondrial thiol groups and that, beyond causing a slight depression of the membrane potential, it has no inhibitory effect on mitochondrial calcium uptake. | URI: | https://hdl.handle.net/10316/5433 | DOI: | 10.1016/S0014-2999(01)00745-2 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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file5f6c841c441d48249825a06f88c5eaa7.pdf | 159.83 kB | Adobe PDF | View/Open |
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