Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5433
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dc.contributor.authorOliveira, Paulo J.-
dc.contributor.authorCoxito, Pedro M.-
dc.contributor.authorRolo, Anabela P.-
dc.contributor.authorSantos, Dario L.-
dc.contributor.authorPalmeira, Carlos M.-
dc.contributor.authorMoreno, António J. M.-
dc.date.accessioned2008-09-01T15:42:12Z-
dc.date.available2008-09-01T15:42:12Z-
dc.date.issued2001en_US
dc.identifier.citationEuropean Journal of Pharmacology. 412:3 (2001) 231-237en_US
dc.identifier.urihttp://hdl.handle.net/10316/5433-
dc.description.abstractThe mitochondrial permeability transition is a widely studied, but poorly understood, phenomenon in mitochondrial bioenergetics. It has been recognised that this phenomenon is related to the opening of a protein pore in the inner mitochondrial membrane, and that opening of this pore is the cause of some forms of mitochondrial dysfunction. In this work, we propose that carvedilol, a multi-role cardioprotective compound, may act as an inhibitor of the high-conductance state of the mitochondrial permeability transition pore, a conclusion supported by the finding that carvedilol provides differential protection against mitochondrial swelling in sucrose and KCl-based media, and that it is unable to protect against calcium-induced depolarisation of the mitochondrial membrane. We also show that carvedilol inhibits the oxidation of mitochondrial thiol groups and that, beyond causing a slight depression of the membrane potential, it has no inhibitory effect on mitochondrial calcium uptake.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T1J-4292HK0-5/1/3f9b42626ac2f0c2ab80880219b5d9c1en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleInhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition poreen_US
dc.typearticleen_US
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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