Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5311
Title: Regulation of AMPA receptors and synaptic plasticity
Authors: Santos, S. D. 
Carvalho, A. L. 
Caldeira, M. V. 
Duarte, C. B. 
Keywords: long-term potentiation; long-term depression; glutamate; receptor trafficking; receptor phosphorylation
Issue Date: 1-Sep-2008
Keywords: long-term potentiation; long-term depression; glutamate; receptor trafficking; receptor phosphorylation
Issue Date: 1-Sep-2008
Citation: Neuroscience. In Press, Corrected Proof:
Abstract: Neuronal activity controls the strength of excitatory synapses by mechanisms that include changes in the postsynaptic responses mediated by AMPA receptors. These receptors account for most fast responses at excitatory synapses of the CNS, and their activity is regulated by various signaling pathways which control the electrophysiological properties of AMPA receptors and their interaction with numerous intracellular regulatory proteins. AMPA receptor phosphorylation/dephosphorylation and interaction with other proteins control their recycling and localization to defined postsynaptic sites, thereby regulating the strength of the synapse. This review focuses on recent advances in the understanding of the molecular mechanisms of regulation of AMPA receptors, and the implications in synaptic plasticity.
URI: http://hdl.handle.net/10316/5311
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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