Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5311
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dc.contributor.authorSantos, S. D.-
dc.contributor.authorCarvalho, A. L.-
dc.contributor.authorCaldeira, M. V.-
dc.contributor.authorDuarte, C. B.-
dc.date.accessioned2008-09-01T15:40:04Z-
dc.date.available2008-09-01T15:40:04Z-
dc.date.issued2008-09-01T15:40:04Z-
dc.identifier.citationNeuroscience. In Press, Corrected Proof:en_US
dc.identifier.urihttp://hdl.handle.net/10316/5311-
dc.description.abstractNeuronal activity controls the strength of excitatory synapses by mechanisms that include changes in the postsynaptic responses mediated by AMPA receptors. These receptors account for most fast responses at excitatory synapses of the CNS, and their activity is regulated by various signaling pathways which control the electrophysiological properties of AMPA receptors and their interaction with numerous intracellular regulatory proteins. AMPA receptor phosphorylation/dephosphorylation and interaction with other proteins control their recycling and localization to defined postsynaptic sites, thereby regulating the strength of the synapse. This review focuses on recent advances in the understanding of the molecular mechanisms of regulation of AMPA receptors, and the implications in synaptic plasticity.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T0F-4RY8SVM-1/1/3cb7cba1ec2f3ed2a75e717661b8a5bden_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectlong-term potentiationen_US
dc.subjectlong-term depressionen_US
dc.subjectglutamateen_US
dc.subjectreceptor traffickingen_US
dc.subjectreceptor phosphorylationen_US
dc.titleRegulation of AMPA receptors and synaptic plasticityen_US
dc.typearticleen_US
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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