Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/5192
Title: Electrochemical detection of in situ adriamycin oxidative damage to DNA
Authors: Oliveira-Brett, A. M. 
Vivan, M. 
Fernandes, I. R. 
Piedade, J. A. P. 
Keywords: Adriamycin; DNA-biosensor; Oxidative damage; 8-Oxoguanine; Voltammetry
Issue Date: 2002
Citation: Talanta. 56:5 (2002) 959-970
Abstract: Adriamycin intercalation and in situ interaction with double helix DNA was investigated using a voltammetric DNA-biosensor. Oxidation and reduction of adriamycin molecules intercalated in double helix DNA were investigated in order to understand the in vivo mechanism of action with this anti-neoplasic drug. The results showed that the interaction of adriamycin with DNA is potential-dependent causing contact between DNA guanine and adenine bases and the electrode surface such that their oxidation is easily detected. A mechanism for adriamycin reduction and oxidation in situ when intercalated in double helix DNA immobilised onto the glassy carbon electrode surface is presented and the formation of the mutagenic 8-oxoguanine explained.
URI: https://hdl.handle.net/10316/5192
DOI: 10.1016/S0039-9140(01)00656-7
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
file1cc3b0c62ec84011af7d7ac3c95dd182.pdf217.2 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

141
checked on Oct 14, 2024

WEB OF SCIENCETM
Citations

135
checked on Oct 2, 2024

Page view(s) 50

646
checked on Nov 5, 2024

Download(s)

384
checked on Nov 5, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.