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Title: Electrochemical determination of 8-oxoguanine in the presence of uric acid
Authors: Rebelo, Isabel 
Piedade, José António P. 
Brett, Ana Maria Oliveira 
Keywords: 8-Oxoguanine; Uric acid; Oxidation; Voltammetry; Differential pulse voltammetry
Issue Date: 2004
Citation: Bioelectrochemistry. 63:1-2 (2004) 267-270
Abstract: The electrochemical oxidation of 8-oxoguanine (8-oxoG) in the presence of uric acid (UA) was studied by differential pulse voltammetry over a wide pH range (1-12). The results showed that both compounds follow a pH-dependent oxidation mechanism that involves two electrons and two protons corresponding to reversible charge transfer reactions. The difference between the peak potential for the oxidation of each analyte was found to be always less than 100 mV over the whole pH range, the separation being greater in the pH interval 4-7. In mixtures of both analytes, pH 6 was shown to be the best for 8-oxoG determination in the presence of uric acid, since the peak current is higher and a greater peak separation is achieved.
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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