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Title: Atomic force microscopy characterization of an electrochemical DNA-biosensor
Authors: Paquim, Ana Maria Chiorcea 
Brett, Ana Maria Oliveira 
Keywords: DNA-biosensor; Atomic force microscopy
Issue Date: 2004
Citation: Bioelectrochemistry. 63:1-2 (2004) 229-232
Abstract: Electrode surface characteristics represent an important aspect on the construction of sensitive DNA electrochemical biosensors for rapid detection of DNA interaction and damage. Two different immobilization procedures of double-stranded DNA (dsDNA) at the surface of a HOPG electrode were evaluated by MAC mode AFM performed in air. A thin dsDNA adsorbed film forming a network structure with holes exposing the electrode surface and a thick dsDNA film completely covering the electrode surface, presenting a much rougher structure, were investigated. The DNA surface characteristics and structure are discussed with respect to the degree of surface coverage.
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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