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https://hdl.handle.net/10316/4841
Title: | Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release | Authors: | Cunha, Rodrigo A. Malva, João O. Ribeiro, J. A. |
Keywords: | Kainate receptor; G protein; Protein kinase C; Hippocampus | Issue Date: | 2000 | Citation: | FEBS Letters. 469:2-3 (2000) 159-162 | Abstract: | Kainate receptors are ionotropic receptors, also reported to couple to Gi/Go proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue, domoate (3 [mu]M), inhibited by 24% [3H]GABA-evoked release, an effect reduced by 76% in synaptosomes pre-treated with pertussis toxin. Protein kinase C inhibition attenuated by 82% domoate-induced inhibition of GABA release whereas protein kinase C activation did not change kainate receptor binding. Thus, domoate inhibition of GABA release recruits Gi/Go proteins and a protein kinase C pathway. | URI: | https://hdl.handle.net/10316/4841 | DOI: | 10.1016/S0014-5793(00)01272-2 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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file616abc6b2e7345b3b67d3b49194da4f5.pdf | 115.5 kB | Adobe PDF | View/Open |
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