Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4841
DC Field | Value | Language |
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dc.contributor.author | Cunha, Rodrigo A. | - |
dc.contributor.author | Malva, João O. | - |
dc.contributor.author | Ribeiro, J. A. | - |
dc.date.accessioned | 2008-09-01T14:15:23Z | - |
dc.date.available | 2008-09-01T14:15:23Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | FEBS Letters. 469:2-3 (2000) 159-162 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/4841 | - |
dc.description.abstract | Kainate receptors are ionotropic receptors, also reported to couple to Gi/Go proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue, domoate (3 [mu]M), inhibited by 24% [3H]GABA-evoked release, an effect reduced by 76% in synaptosomes pre-treated with pertussis toxin. Protein kinase C inhibition attenuated by 82% domoate-induced inhibition of GABA release whereas protein kinase C activation did not change kainate receptor binding. Thus, domoate inhibition of GABA release recruits Gi/Go proteins and a protein kinase C pathway. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6T36-3YRVBPH-6/1/a4d0cd3bf73cd3eea2d7e666afc0bdd4 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Kainate receptor | en_US |
dc.subject | G protein | en_US |
dc.subject | Protein kinase C | en_US |
dc.subject | Hippocampus | en_US |
dc.title | Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/S0014-5793(00)01272-2 | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
crisitem.author.orcid | 0000-0002-5438-4447 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
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file616abc6b2e7345b3b67d3b49194da4f5.pdf | 115.5 kB | Adobe PDF | View/Open |
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