Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4838
Title: | Analytical method for the determination of strychnine in tissues by gas chromatography/mass spectrometry: two case reports | Authors: | Marques, E. P. Gil, F. Proença, P. Monsanto, P. Oliveira, M. F. Castanheira, A. Vieira, D. N. |
Keywords: | Strychnine; Rodenticide; Alkaloid | Issue Date: | 2000 | Citation: | Forensic Science International. 110:2 (2000) 145-152 | Abstract: | This paper describes an analytical method for strychnine determination in biological samples by gas chromatography/mass spectrometry and their application in the investigation of two cases involving strychnine ingestion: A fatal case and a clinical one. The strychnine is isolated from biological samples using a liquid-liquid extraction procedure. The clean-up procedure is performed using an acid solution. Papaverine is used as internal standard in the quantification of strychnine. In the analysed specimens, the limits of quantification were 0.1 [mu]g/ml or 0.1 [mu]g/g. The recovery rate ranged from 75.0% to 98.7% and the coefficients of variation ranged from 4.8% to 10.5%. | URI: | https://hdl.handle.net/10316/4838 | DOI: | 10.1016/S0379-0738(00)00153-5 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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file6efd8f7d90ce4a2e8aae18941b4af33d.pdf | 87.16 kB | Adobe PDF | View/Open |
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