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Title: Analytical method for the determination of strychnine in tissues by gas chromatography/mass spectrometry: two case reports
Authors: Marques, E. P. 
Gil, F. 
Proença, P. 
Monsanto, P. 
Oliveira, M. F. 
Castanheira, A. 
Vieira, D. N. 
Keywords: Strychnine; Rodenticide; Alkaloid
Issue Date: 2000
Citation: Forensic Science International. 110:2 (2000) 145-152
Abstract: This paper describes an analytical method for strychnine determination in biological samples by gas chromatography/mass spectrometry and their application in the investigation of two cases involving strychnine ingestion: A fatal case and a clinical one. The strychnine is isolated from biological samples using a liquid-liquid extraction procedure. The clean-up procedure is performed using an acid solution. Papaverine is used as internal standard in the quantification of strychnine. In the analysed specimens, the limits of quantification were 0.1 [mu]g/ml or 0.1 [mu]g/g. The recovery rate ranged from 75.0% to 98.7% and the coefficients of variation ranged from 4.8% to 10.5%.
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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