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Title: Topographical functional connectivity patterns exist in the congenitally, prelingually deaf
Authors: Striem-Amit, Ella 
Almeida, Jorge 
Belledonne, Mario 
Chen, Quanjing 
Fang, Yuxing 
Han, Zaizhu 
Caramazza, Alfonso 
Bi, Yanchao 
Issue Date: 2016
Project: info:eu-repo/grantAgreement/EC/H2020/654837/EU/Embodied and Abstract Concepts in Sensory-motor Deprivation 
Serial title, monograph or event: Scientific Reports
Volume: 6
Issue: 1
Abstract: Congenital deafness causes large changes in the auditory cortex structure and function, such that without early childhood cochlear-implant, profoundly deaf children do not develop intact, high-level, auditory functions. But how is auditory cortex organization affected by congenital, prelingual, and long standing deafness? Does the large-scale topographical organization of the auditory cortex develop in people deaf from birth? And is it retained despite cross-modal plasticity? We identified, using fMRI, topographic tonotopy-based functional connectivity (FC) structure in humans in the core auditory cortex, its extending tonotopic gradients in the belt and even beyond that. These regions show similar FC structure in the congenitally deaf throughout the auditory cortex, including in the language areas. The topographic FC pattern can be identified reliably in the vast majority of the deaf, at the single subject level, despite the absence of hearing-aid use and poor oral language skills. These findings suggest that large-scale tonotopic-based FC does not require sensory experience to develop, and is retained despite life-long auditory deprivation and cross-modal plasticity. Furthermore, as the topographic FC is retained to varying degrees among the deaf subjects, it may serve to predict the potential for auditory rehabilitation using cochlear implants in individual subjects.
DOI: 10.1038/srep29375
Rights: openAccess
Appears in Collections:I&D CINEICC - Artigos em Revistas Internacionais

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