Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/46917
Title: Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
Authors: Mendes, Cristina 
Salgueiro, Patrícia 
Gonzalez, Vicenta 
Berzosa, Pedro 
Benito, Agustin 
Rosário, Virgílio E. do 
Sousa, Bruno de 
Cano, Jorge 
Arez, Ana Paula 
Keywords: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Culicidae; DNA, Protozoan; Equatorial Guinea; Female; Genes, Protozoan; Humans; Infant; Malaria; Male; Middle Aged; Plasmodium; Point Mutation; Polymerase Chain Reaction; Selection, Genetic; Young Adult; Drug Resistance; Genetic Markers; Genetic Variation
Issue Date: 2013
Serial title, monograph or event: Malaria Journal
Volume: 12
Issue: 1
Abstract: In Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity and population structure should be studied in both hosts to properly assess their effects on infection and transmission dynamics. This study aimed to characterize the circulating populations of Plasmodium spp and Plasmodium falciparum from a combined set of human blood and mosquito samples gathered in mainland Equatorial Guinea. Further, the origin and evolution of anti-malarial resistance in this area, where malaria remains a major public health problem were traced.
URI: https://hdl.handle.net/10316/46917
DOI: 10.1186/1475-2875-12-114
Rights: openAccess
Appears in Collections:I&D CINEICC - Artigos em Revistas Internacionais

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