Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45111
Title: A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins
Authors: Marques, Joana 
Santos, Teresa M. 
Marques, Maria Paula 
Braga, Susana S. 
Keywords: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Glycine; Humans; Osteosarcoma; beta-Cyclodextrins
Issue Date: 2009
Serial title, monograph or event: Dalton Transactions
Issue: 44
Abstract: The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.
URI: http://hdl.handle.net/10316/45111
Other Identifiers: 10.1039/b915839a
DOI: 10.1039/b915839a
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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