Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45111
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dc.contributor.authorMarques, Joana-
dc.contributor.authorSantos, Teresa M.-
dc.contributor.authorMarques, Maria Paula-
dc.contributor.authorBraga, Susana S.-
dc.date.accessioned2017-12-15T18:06:05Z-
dc.date.available2017-12-15T18:06:05Z-
dc.date.issued2009-
dc.identifier10.1039/b915839a-
dc.identifier.urihttp://hdl.handle.net/10316/45111-
dc.description.abstractThe complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAntineoplastic Agentspor
dc.subjectBone Neoplasmspor
dc.subjectCell Line, Tumorpor
dc.subjectCell Proliferationpor
dc.subjectCoordination Complexespor
dc.subjectGlycinepor
dc.subjectHumanspor
dc.subjectOsteosarcomapor
dc.subjectbeta-Cyclodextrinspor
dc.titleA glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrinspor
dc.typearticle-
degois.publication.firstPage9812por
degois.publication.issue44por
degois.publication.titleDalton Transactionspor
dc.peerreviewedyespor
dc.identifier.doi10.1039/b915839apor
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitMolecular Physical-Chemistry-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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