Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/44923
DC FieldValueLanguage
dc.contributor.authorFerreira, José Augusto-
dc.contributor.authorGrassi, Mario-
dc.contributor.authorGudiño, Elias-
dc.contributor.authorOliveira, Paula de-
dc.date.accessioned2017-12-12T18:24:01Z-
dc.date.available2017-12-12T18:24:01Z-
dc.date.issued2013-
dc.identifier.urihttp://hdl.handle.net/10316/44923-
dc.description.abstractWe propose a one-dimensional model to describe the sorption of a solvent by a polymeric membrane, followed by polymer swelling and drug release. We assume that the solvent diffuses into the membrane and induces a stress driven diffusion, that causes a non-Fickian mass flux. We assume that the drug is present in two states (dissolved and undissolved) and that its transport occurs by Fickian diffusion and non-linear dissolution. Polymer swelling is tracked with a volume conservation equation. The system of partial differential equations that define the model is numerically solved. A qualitative analysis of the dependence of the solutions on the parameters of the model shows a complete agreement with the expected physical behavior.por
dc.language.isoengpor
dc.publisherCMMSEpor
dc.relationPEst-C/MAT/UI0324/2011por
dc.rightsopenAccesspor
dc.titleA mathematical model for controlled drug delivery in swelling polymerspor
dc.typearticlepor
degois.publication.firstPage630por
degois.publication.lastPage641por
degois.publication.locationAlmería, Spainpor
degois.publication.titleProceedings of the 13th International Conference on Computational and Mathematical Methods in Science and Engineering - CMMSE 2013por
dc.peerreviewedyespor
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCenter for Mathematics, University of Coimbra-
crisitem.author.researchunitCenter for Mathematics, University of Coimbra-
crisitem.author.orcid0000-0002-5226-2905-
crisitem.author.orcid0000-0001-6634-6651-
Appears in Collections:I&D CMUC - Artigos e Resumos em Livros de Actas
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