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https://hdl.handle.net/10316/44923
Título: | A mathematical model for controlled drug delivery in swelling polymers | Autor: | Ferreira, José Augusto Grassi, Mario Gudin͂o, Elias Oliveira, Paula de |
Data: | 2013 | Editora: | CMMSE | Projeto: | PEst-C/MAT/UI0324/2011 | Título da revista, periódico, livro ou evento: | Proceedings of the 13th International Conference on Computational and Mathematical Methods in Science and Engineering - CMMSE 2013 | Local de edição ou do evento: | Almería, Spain | Resumo: | We propose a one-dimensional model to describe the sorption of a solvent by a polymeric membrane, followed by polymer swelling and drug release. We assume that the solvent diffuses into the membrane and induces a stress driven diffusion, that causes a non-Fickian mass flux. We assume that the drug is present in two states (dissolved and undissolved) and that its transport occurs by Fickian diffusion and non-linear dissolution. Polymer swelling is tracked with a volume conservation equation. The system of partial differential equations that define the model is numerically solved. A qualitative analysis of the dependence of the solutions on the parameters of the model shows a complete agreement with the expected physical behavior. | URI: | https://hdl.handle.net/10316/44923 | Direitos: | openAccess |
Aparece nas coleções: | I&D CMUC - Artigos e Resumos em Livros de Actas |
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JAF_EG_PO.pdf | 629.44 kB | Adobe PDF | Ver/Abrir |
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