Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/33276
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Fernandes, Rosa Cristina Simões | - |
dc.contributor.advisor | Reis, Flávio Nelson Fernandes | - |
dc.contributor.author | João, Ana Luísa de Natividade Faria | - |
dc.date.accessioned | 2016-12-09T09:19:08Z | - |
dc.date.available | 2016-12-09T09:19:08Z | - |
dc.date.issued | 2016-01 | - |
dc.identifier.uri | https://hdl.handle.net/10316/33276 | - |
dc.description | Trabalho de revisão do 6º ano médico com vista á atribuição do grau de mestre (área científica de farmacologia) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina. | por |
dc.description.abstract | Abstract Incretins are gastrointestinal-derived hormones released in response to a meal that play a key role in the regulation of postprandial secretion of insulin (incretin effect) and glucagon by the pancreas. Both incretins, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have several other actions. GLP-1 regulates body weight by inhibiting appetite and delaying gastric emptying, actions that are dependent on central nervous system GLP-1 receptor activation. Several other hormones and gut peptides, including leptin and ghrelin, interact with GLP-1 to modulate appetite. GLP-1 is labile, being rapidly degraded by dipeptidyl peptidase-4 (DPP-4), a multifunction molecule whose role in obesity dynamics extends beyond incretin metabolism. DPP-4 is involved in adipose tissue inflammation, which is a pivotal event in insulin resistance and a key pathophysiological mechanism in the genesis of obesity-related complications. Furthermore, the incretin system appears to provide the basis for understanding the high weight loss efficacy of bariatric surgery, a current employed obesity treatment that also benefits diabetes. The present review brings together new insights into obesity pathogenesis, integrating GLP-1 and DPP-4 in the complex interplay between obesity epidemics and inflammation, namely in diabetic patients. This will in turn provide the basis for new perspectives regarding GLP-1 receptor agonists and DPP-4 inhibitors therapeutic potential. | por |
dc.language.iso | eng | por |
dc.rights | openAccess | por |
dc.subject | Incretin-based therapies | por |
dc.subject | Glucagon-like peptide-1 (GLP-1) | por |
dc.subject | Dipeptidyl peptidase-4 (DPP-4) | por |
dc.subject | Obesity | por |
dc.subject | Type 2 diabetes mellitus (T2DM), | por |
dc.subject | Bariatric surgery | por |
dc.subject | Inflammation | por |
dc.title | The incretin abc's in helath and disease-novel approaches to obesity and diabetes treatment | por |
dc.type | masterThesis | por |
thesis.degree.name | Mestrado Integrado em Medicina | por |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | masterThesis | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.advisor.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.advisor.orcid | 0000-0003-3401-9554 | - |
Appears in Collections: | UC - Dissertações de Mestrado FMUC Medicina - Teses de Mestrado |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ana Luísa João FMUC 2016.pdf | Ana Luísa João FMUC 2016 | 1.05 MB | Adobe PDF | View/Open |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.