Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/27162
Título: Helichrysum italicum: from traditional use to scientific data
Autor: Viegas, Daniel Antunes 
Palmeira-de-Oliveira, Ana 
Salgueiro, Lígia 
Martinez-de-Oliveira, José 
Palmeira-de-Oliveira, Rita 
Palavras-chave: Helichrysum italicum; Traditional medicine; Everlasting; Anti-inflammatory; Antimicrobial
Data: 10-Jan-2014
Editora: Elsevier
Citação: VIEGAS, Daniel Antunes. [et al.] - Helichrysum italicum: from traditional use to scientific data. "Journal of Ethnopharmacology". ISSN 0378-8741. Vol. 151 Nº. 1 (2014) p. 54-65
Título da revista, periódico, livro ou evento: Journal of Ethnopharmacology
Volume: 151
Número: 1
Resumo: Ethnopharmacological relevance Helichrysum italicum (Roth) G. Don fil. (family Asteraceae) has been used for its medicinal properties for a long time and, even nowadays, continues to play an important role in the traditional medicine of Mediterranean countries. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. This review aims to provide an overview of the current state of knowledge of the pharmacological activities of Helichrysum italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methods The selection of relevant data was made through a search using the keywords “Helichrysum italicum” and “H. italicum” in “Directory of Open Access Journals”, “Google Scholar”, “ISI Web of Knowledge”, “PubMed”, “ScienceDirect” and “Wiley Online Library”. Information obtained in local and foreign books and other sources was also included. Results There are reports on the traditional use of Helichrysum italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections and sleeplessness. In order to validate some of the traditional uses of Helichrysum italicum and highlight other potential applications for its extracts and isolated compounds, several scientific studies have been conducted in the last decades. In vitro studies characterized Helichrysum italicum as an antimicrobial and anti-inflammatory agent. Its flavonoids and terpenes were effective against bacteria (e.g. Staphylococcus aureus), its acetophenones, phloroglucinols and terpenoids displayed antifungal action against Candida albicans and its flavonoids and phloroglucinols inhibited HSV and HIV, respectively. Helichrysum italicum acetophenones, flavonoids and phloroglucinols demonstrated inhibitory action in different pathways of arachidonic acid metabolism and other pro-inflammatory mediators. Regarding Helichrysum italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acetophenones and phloroglucinols, as seen in animal models. Concerning its safety and adverse effects, while Helichrysum italicum does not display significant levels of cytotoxicity or genotoxicity, it should be noticed that one of its flavonoids inhibited some CYP isoforms and a case has been reported of an allergic reaction to its extracts. Conclusions Helichrysum italicum is a medicinal plant with promising pharmacological activities. However, most of its traditionally claimed applications are not yet scientifically proven. Clinical trials are needed to further confirm these data and promote Helichrysum italicum as an important tool in the treatment of several diseases.
URI: https://hdl.handle.net/10316/27162
ISSN: 0378-8741
DOI: 10.1016/j.jep.2013.11.005
Direitos: openAccess
Aparece nas coleções:FFUC- Artigos em Revistas Internacionais
I&D CEFarmacêuticos - Artigos em Revistas Internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato
Helichrysum italicum From traditional use to scientific data.pdf1.56 MBAdobe PDFVer/Abrir
Mostrar registo em formato completo

Citações SCOPUSTM   

129
Visto em 26/fev/2024

Citações WEB OF SCIENCETM
5

110
Visto em 2/out/2023

Visualizações de página 50

642
Visto em 26/mar/2024

Downloads 5

7.501
Visto em 26/mar/2024

Google ScholarTM

Verificar

Altmetric

Altmetric


Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.