Please use this identifier to cite or link to this item:
Title: Poly(ethylene glycol)-block-poly(4-vinyl pyridine) as a versatile block copolymer to prepare nanoaggregates of superparamagnetic iron oxide nanoparticles
Authors: Rocha, Nuno 
Mendes, Joana 
Durães, Luísa 
Maleki, Hajar 
Portugal, António 
Geraldes, C. F. G. C. 
Serra, Arménio 
Coelho, Jorge 
Issue Date: 2014
Publisher: The Royal Society of Chemistry
Serial title, monograph or event: Journal of Materials Chemistry B
Volume: 2
Issue: 11
Abstract: This work reports an efficient method for the preparation of aqueous dispersions of superparamagnetic iron oxide nanoparticles (SPIONs), involving the use of an amphiphilic block copolymer, poly(ethylene glycol)- block-poly(4-vinyl pyridine) (mPEG-b-P4VP). The iron oxide nanoparticles are easily and efficiently dispersed due to the strong direct interaction of the hydrophobic P4VP segments, through complexation with pyridine units of the copolymer. Well-defined block copolymers, having different compositions and molecular weights, were prepared by atom transfer radical polymerization (ATRP). The aqueous selfassembly behavior of each system has been compared based on the method of preparation. The results revealed that the addition of ionic species has a significant effect on the size and type of formed nanostructures, the magnitude of which is dependent on the block copolymers' molecular design. When similar self-assembly strategies were used in the presence of SPIONs, the same type of nanostructures was formed. The hybrid SPION nanoaggregates were investigated using NMR relaxometric techniques, whereby high r2/r1 relaxivity ratios were achieved, making these materials potentially efficient T2- weighted MRI contrast agents.
DOI: 10.1039/c3tb21454k
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
I&D CIEPQPF - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
c3tb21454k.pdf1.01 MBAdobe PDFView/Open
Show full item record


checked on Nov 11, 2022

Citations 5

checked on May 2, 2023

Page view(s) 50

checked on Jun 12, 2024

Download(s) 10

checked on Jun 12, 2024

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.