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https://hdl.handle.net/10316/24816
Título: | Suicide gene therapy in cancer: Where do we stand now? | Autor: | Duarte, Sónia Carle, Georges Faneca, Henrique Lima, Maria C. Pedroso de Pierrefite-Carle, Valérie |
Palavras-chave: | Suicide gene therapy; Cancer; Bystander effect; Combined strategies | Data: | Nov-2012 | Editora: | Elsevier | Citação: | DUARTE, Sónia [et al.] - Suicide gene therapy in cancer: Where do we stand now?. "Cancer Letters". ISSN 0304-3835. 324:2 (2012) 160-170 | Título da revista, periódico, livro ou evento: | Cancer Letters | Volume: | 324 | Número: | 2 | Resumo: | Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial gene, which allows the conversion of a non-toxic compound into a lethal drug. Although suicide gene therapy has been successfully used in a large number of in vitro and in vivo studies, its application to cancer patients has not reached the desirable clinical significance. However, recent reports on pre-clinical cancer models demonstrate the huge potential of this strategy when used in combination with new therapeutic approaches. In this review, we summarize the different suicide gene systems and gene delivery vectors addressed to cancer, with particular emphasis on recently developed systems and associated bystander effects. In addition, we review the different strategies that have been used in combination with suicide gene therapy and provide some insights into the future directions of this approach, particularly towards cancer stem cell eradication. | URI: | https://hdl.handle.net/10316/24816 | ISSN: | 0304-3835 | DOI: | 10.1016/j.canlet.2012.05.023 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Ficheiros deste registo:
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Suicide gene therapy in cancer.pdf | 584.86 kB | Adobe PDF | Ver/Abrir |
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