Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/21646
DC Field | Value | Language |
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dc.contributor.author | Natu, Mădălina V. | - |
dc.contributor.author | Gaspar, Manuel N. | - |
dc.contributor.author | Ribeiro, Carlos A. Fontes | - |
dc.contributor.author | Correia, Ilídio J. | - |
dc.contributor.author | Silva, Daniela | - |
dc.contributor.author | Sousa, Hermínio C. de | - |
dc.contributor.author | Gil, M. H. | - |
dc.date.accessioned | 2013-02-14T14:40:10Z | - |
dc.date.available | 2013-02-14T14:40:10Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | NATU, Mădălina V. [et al.] - A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug. "Biomedical Materials". ISSN 1748-60416. 6:2 (2011) 9 p. | por |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.uri | https://hdl.handle.net/10316/21646 | - |
dc.description.abstract | Implantable dorzolamide-loaded discs were prepared by blending poly(ε-caprolactone), PCL, with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), Lu. By blending, crystallinity, water uptake and mass loss were modified relative to the pure polymers. Burst was diminished by coating the discs with a PCL shell. All samples presented burst release except PCL-coated samples that showed controlled release during 18 days. For PCL-coated samples, barrier control of diffusion coupled with partition control from the core slowed down the release, while for 50/50 Lu/PCL-coated samples, the enhancement in the porosity of the core diminished partition control of drug release. Nonlinear regression analysis suggested that a degradation model fully describes the release curve considering a triphasic release mechanism: the instantaneous diffusion (burst), diffusion and polymer degradation stages. The MTT test indicated that the materials are not cytotoxic for corneal endothelial cells. A good in vitro–in vivo correlation was obtained, with similar amounts of drug released in vitro and in vivo. The discs decreased intraocular pressure (IOP) in normotensive rabbit eyes by 13.0% during 10 days for PCL-coated and by 13.0% during 4 days for 50/50 Lu/PCL-coated samples. The percentages of IOP decrease are similar to those obtained by dorzolamide eyedrop instillation (11.0%). | por |
dc.language.iso | eng | por |
dc.publisher | IOP Publishing | por |
dc.rights | closedAccess | por |
dc.title | A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug | por |
dc.type | article | por |
degois.publication.firstPage | 9 p. | por |
degois.publication.issue | 2 | por |
degois.publication.title | Biomedical Materials | por |
dc.date.embargoEndDate | 10000-01-01 | - |
dc.relation.publisherversion | http://iopscience.iop.org/1748-605X/6/2/025003 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1088/1748-6041/6/2/025003 | - |
degois.publication.volume | 6 | por |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | reserved | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-9707-4895 | - |
crisitem.author.orcid | 0000-0003-1613-9675 | - |
crisitem.author.orcid | 0000-0002-2629-7805 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais FCTUC Eng.Química - Artigos em Revistas Internacionais |
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File | Description | Size | Format | Login |
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2011 BM Natu.pdf | 650.21 kB | Adobe PDF | Request a copy |
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