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https://hdl.handle.net/10316/18512
Title: | Drugs of abuse induce apoptotic features in PC12 cells. | Authors: | Oliveira, M. Teresa Rego, A. Cristina Macedo, Tice R. Oliveira, Catarina R. |
Issue Date: | 8-Mar-2012 | Serial title, monograph or event: | Annals of the New York Academy of Sciences | Volume: | 1010 | Abstract: | Drugs of abuse induce the release of dopamine in the central nervous system, particularly in the mesolimbic-mesocortical pathway. As dopamine may act as a neurotoxin, in this study, we analyzed the effects of the drugs of abuse, cocaine, heroin, and amphetamine, on the neurodegeneration of PC12 cells, a dopaminergic cell line, by evaluating the activity of caspase-3 and mitochondrial cytochrome c release. All the drugs were shown to induce caspase-3 activation, similarly to staurosporine, a classical inducer of apoptotic cell death. Furthermore, like staurosporine, the drugs of abuse induced a decrease in mitochondrial cytochrome c content, suggesting the involvement of the mitochondrial apoptotic pathway. | URI: | https://hdl.handle.net/10316/18512 | DOI: | 10.1196/annals.1299.121 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Oliveira et al. - 2003 - Annals of the New York Academy of Sciences.pdf | 2.04 MB | Adobe PDF | View/Open |
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