Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/116157
Título: Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity
Autor: Sousa, Diana Isabel Teixeira de 
Magalhães, Carina C. 
Matafome, Paulo 
Pereira, Susana P. 
Palavras-chave: Gestational obesity; Intrahepatic lipid accumulation; Maternal metabolic health; Metabolic Dysfunction-Associated Steatotic Liver Disease; Molecular bases of diseases; hepatic steatosis
Data: 28-Ago-2024
Projeto: info:eu-repo/grantAgreement/HE/101087071/CHAngeing 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/04539/2020 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP/04539/2020 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA/P/0058/2020/PT 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/00617/2020 
Título da revista, periódico, livro ou evento: Bioscience Reports
Volume: 44
Número: 8
Resumo: Obesity during pregnancy has been escalating, becoming a huge problem that poses consequences not only for the health of the offspring but also for the maternal well-being. Women's adipose and hepatic tissue metabolism undergoes significant changes during the gestational period. During pregnancy, obesity is a primary instigator of steatosis, increasing the risk of non-alcholic fatty liver disease (NAFLD), now recognized under the updated nomenclature metabolic dysfunction-associated steatotic liver disease (MASLD). Pregnant women with obesity present higher levels of free fatty acids and glucose, reduction in insulin sensitivity, and adipose tissue endocrine dysregulation. Furthermore, obesity-induced modifications in clock genes and lipid-associated gene expression within adipose tissue disrupt crucial metabolic adaptations, potentially culminating in adipose tissue dysfunction. Thus, the liver experiences increased exposure to free fatty acids through the portal vein. Higher uptake of free fatty acids into the liver disrupts hepatic lipid oxidation while enhances lipogenesis, thereby predisposing to ectopic fat deposition within the liver. This review focuses on the obesity-induced changes during pregnancy in both liver and adipose tissue metabolism, elucidating how the metabolic crosstalk between these two organs can be dysregulated in pregnant women living with obesity.
URI: https://hdl.handle.net/10316/116157
ISSN: 0144-8463
1573-4935
DOI: 10.1042/BSR20231679
Direitos: openAccess
Aparece nas coleções:I&D ICBR - Artigos em Revistas Internacionais

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