Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/116126| Title: | Cellular reprogramming as a tool to model human aging in a dish | Authors: | Pitrez, Patrícia R. Monteiro, Luís M. Borgogno, Oliver Nissan, Xavier Mertens, Jerome Ferreira, Lino |
Issue Date: | 28-Feb-2024 | Publisher: | Nature Research | Project: | info:eu-repo/grantAgreement/FCT/PTDC/BTM-SAL/5174/2020 info:eu-repo/grantAgreement/HE/101087071/CHAngeing info:eu-repo/grantAgreement/FCT/2022.07615.PTDC info:eu-repo/grantAgreement/H2020/952266/RESETageing info:eu-repo/grantAgreement/HE/101129812/REGENERAR info:eu-repo/grantAgreement/HE/101080229/DREAMS |
Serial title, monograph or event: | Nature Communications | Volume: | 15 | Issue: | 1 | Abstract: | The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions. | URI: | https://hdl.handle.net/10316/116126 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-024-46004-5 | Rights: | openAccess |
| Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| s41467-024-46004-5.pdf | 2.68 MB | Adobe PDF | View/Open |
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