Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/116126
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pitrez, Patrícia R. | - |
dc.contributor.author | Monteiro, Luís M. | - |
dc.contributor.author | Borgogno, Oliver | - |
dc.contributor.author | Nissan, Xavier | - |
dc.contributor.author | Mertens, Jerome | - |
dc.contributor.author | Ferreira, Lino | - |
dc.date.accessioned | 2024-08-19T11:26:51Z | - |
dc.date.available | 2024-08-19T11:26:51Z | - |
dc.date.issued | 2024-02-28 | - |
dc.identifier.issn | 2041-1723 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/116126 | - |
dc.description.abstract | The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions. | pt |
dc.language.iso | eng | pt |
dc.publisher | Nature Research | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/PTDC/BTM-SAL/5174/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/HE/101087071/CHAngeing | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/2022.07615.PTDC | pt |
dc.relation | info:eu-repo/grantAgreement/H2020/952266/RESETageing | pt |
dc.relation | info:eu-repo/grantAgreement/HE/101129812/REGENERAR | pt |
dc.relation | info:eu-repo/grantAgreement/HE/101080229/DREAMS | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Aging | pt |
dc.subject.mesh | Cellular Reprogramming | pt |
dc.subject.mesh | Longevity | pt |
dc.subject.mesh | Induced Pluripotent Stem Cells | pt |
dc.title | Cellular reprogramming as a tool to model human aging in a dish | pt |
dc.type | article | - |
degois.publication.firstPage | 1816 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Nature Communications | pt |
dc.relation.publisherversion | https://www.nature.com/articles/s41467-024-46004-5 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41467-024-46004-5 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2024-02-28 | * |
uc.date.periodoEmbargo | 0 | pt |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.project.grantno | Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function | - |
crisitem.project.grantno | RESEarch for healThy AGEING | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-3116-0723 | - |
crisitem.author.orcid | 0000-0001-8985-9302 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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s41467-024-46004-5.pdf | 2.68 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License