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https://hdl.handle.net/10316/115003
Título: | Vascular effects of Fragaria vesca L. in human arteries | Autor: | Malheiros, Jéssica Simões, Daniela M. Antunes, Pedro E. Figueirinha, Artur Cotrim, Maria Dulce Fonseca, Diogo A. |
Palavras-chave: | Fragaria vesca L.; infusion; hydroalcoholic extract; vascular effects; human internal thoracic artery | Data: | 2023 | Projeto: | UIDB/50006/2020 UIDP/50006/2020 |
Volume: | 37 | Número: | 22 | Resumo: | Fragaria vesca L. (wild strawberry) is traditionally used for its anti-inflammatory activity and for gastrointestinal, cardiovascular and urinary disorders. A previous study with the rat aorta showed that its leaves extract elicits endothelium-dependent vasorelaxation. Our aim was to investigate the clinical application of Fragaria vesca in vascular disease, by assessing the vascular effects of an infusion and hydroalcoholic extract in internal thoracic arteries from patients with coronary artery disease. The extracts elicited no effects on basal vascular tone and did not induce any vasorelaxation. At low concentration (0.02 mg/mL), the infusion potentiated the noradrenaline-induced contraction, while the other concentrations did not elicit significant changes in efficacy or potency. Differences between our findings and the previous report on rat aorta may result from methodological differences, e.g. vascular bed, method of extraction and extract composition. The clinical applicability of extracts of Fragaria vesca in patients with cardiovascular disease remains to be fully validated. | URI: | https://hdl.handle.net/10316/115003 | ISSN: | 1478-6419 1478-6427 |
DOI: | 10.1080/14786419.2022.2152448 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Vascular-effects-of-Fragaria-vesca-L-in-human-arteriesNatural-Product-Research.pdf | 1.62 MB | Adobe PDF | Ver/Abrir |
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