Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/115003
Title: Vascular effects of Fragaria vesca L. in human arteries
Authors: Malheiros, Jéssica
Simões, Daniela M. 
Antunes, Pedro E. 
Figueirinha, Artur 
Cotrim, Maria Dulce 
Fonseca, Diogo A. 
Keywords: Fragaria vesca L.; infusion; hydroalcoholic extract; vascular effects; human internal thoracic artery
Issue Date: 2023
Project: UIDB/50006/2020 
UIDP/50006/2020 
Volume: 37
Issue: 22
Abstract: Fragaria vesca L. (wild strawberry) is traditionally used for its anti-inflammatory activity and for gastrointestinal, cardiovascular and urinary disorders. A previous study with the rat aorta showed that its leaves extract elicits endothelium-dependent vasorelaxation. Our aim was to investigate the clinical application of Fragaria vesca in vascular disease, by assessing the vascular effects of an infusion and hydroalcoholic extract in internal thoracic arteries from patients with coronary artery disease. The extracts elicited no effects on basal vascular tone and did not induce any vasorelaxation. At low concentration (0.02 mg/mL), the infusion potentiated the noradrenaline-induced contraction, while the other concentrations did not elicit significant changes in efficacy or potency. Differences between our findings and the previous report on rat aorta may result from methodological differences, e.g. vascular bed, method of extraction and extract composition. The clinical applicability of extracts of Fragaria vesca in patients with cardiovascular disease remains to be fully validated.
URI: https://hdl.handle.net/10316/115003
ISSN: 1478-6419
1478-6427
DOI: 10.1080/14786419.2022.2152448
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

Files in This Item:
Show full item record

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons