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https://hdl.handle.net/10316/114911
Title: | Gestational Exercise Antagonises the Impact of Maternal High-Fat High-Sucrose Diet on Liver Mitochondrial Alterations and Quality Control Signalling in Male Offspring | Authors: | Stevanović-Silva, Jelena Beleza, Jorge Coxito, Pedro Oliveira, Paulo J. Ascensão, António Magalhães, José |
Keywords: | gestational diabetes; mitochondrial biogenesis; mitochondrial dynamics; epigenetics; gestational exercise; foetal programming | Issue Date: | 12-Jan-2023 | Publisher: | MDPI | Project: | PTDC/DTP-DES/7087/2014 PTDC/DTPDES/1082/2014 SFRH/BD/129645/2017 info:eu-repo/grantAgreement/H2020/722619/EU/MarieSkłodowska-Curie/FOIEGRAS |
Serial title, monograph or event: | International Journal of Environmental Research and Public Health | Volume: | 20 | Issue: | 2 | Abstract: | Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are relevant modulators of the intrauterine environment, increasing the risk of liver metabolic alterations in mothers and offspring. In contrast, as a non-pharmacological approach against metabolic disorders, exercise is highly recommended in GDM treatment. We analysed whether gestational exercise (GE) protects mothers from diet-induced GDM metabolic consequences and mitigates liver mitochondrial deleterious alterations in their 6-week-old male offspring. Female Sprague Dawley rats were fed with control or high-fat high-sucrose (HFHS) diet and kept sedentary or submitted to GE. Male offspring were sedentary and fed with control diet. Sedentary HFHS mothers and their offspring showed impaired hepatic mitochondrial biogenesis and morphological evidence of mitochondrial remodelling. In contrast, GE-related beneficial effects were demonstrated by upregulation of mitochondrial biogenesis signalling markers and mitochondrial fusion proteins and downregulation of mitochondrial fission protein. Alterations in miR-34a, miR-130b, and miR-494, associated with epigenetic regulation of mitochondrial biogenesis, suggested that GE is a more critical modulator of intergenerational changes in miRs expression than the maternal diet. Our data showed that GE positively modulated the altered hepatic mitochondrial biogenesis and dynamics markers and quality control signalling associated with maternal HFHS-diet-related GDM in mothers and offspring. | URI: | https://hdl.handle.net/10316/114911 | ISSN: | 1660-4601 | DOI: | 10.3390/ijerph20021388 | Rights: | openAccess |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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