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https://hdl.handle.net/10316/114906
Título: | The striatum drives the ergogenic effects of caffeine | Autor: | de Bem Alves, Ana Cristina Speck, Ana Elisa Farias, Hémelin Resende Martins, Leo Meira Dos Santos, Naiara Souza Pannata, Gabriela Tavares, Ana Paula Gomes de Oliveira, Jade Tomé, Ângelo R. Cunha, Rodrigo A. Aguiar, Aderbal S. |
Palavras-chave: | Caffeine; Dopamine; Grip strength; Mitochondria; Neuroplasticity; Striatum | Data: | Dez-2023 | Editora: | Springer Nature | Projeto: | Prémio Maratona da Saúde, CAPES (Demanda Social), CAPES-FCT (039/2014), CNPq (302234/2016-0), LaCaixa Foundation (LCF/PR/HP17/52190001), FAPESC (1664/2017), FCT (POCI-01- 0145-FEDER-03127 and UIDB/04539/2020), and ERDF through Centro 2020 (project CENTRO-01-0145-FEDER-000008: BrainHealth 2020 and CENTRO-01-0246-FEDER-000010). A.S.A.Jr is a CNPq fellow (310635/2020-9) | Título da revista, periódico, livro ou evento: | Purinergic Signalling | Volume: | 19 | Número: | 4 | Resumo: | Caffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported the ergogenic mechanism of caffeine through neuronal A2AR antagonism in the central nervous system [1]. We now demonstrate that the striatum rules the ergogenic effects of caffeine through neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) and twenty-four C57BL/6J (8-10 weeks, 23.9 ± 0.4 g) adult male mice were studied behaviorly and electrophysiologically using caffeine and energy metabolism was studied in SH-SY5Y cells. Systemic (15 mg/kg, i.p.) or striatal (bilateral, 15 μg) caffeine was psychostimulant in the open field (p < 0.05) and increased grip efficiency (p < 0.05). Caffeine also shifted long-term depression (LTD) to potentiation (LTP) in striatal slices and increased the mitochondrial mass (p < 0.05) and membrane potential (p < 0.05) in SH-SY5Y dopaminergic cells. Our results demonstrate the role of the striatum in the ergogenic effects of caffeine, with changes in neuroplasticity and mitochondrial metabolism. | URI: | https://hdl.handle.net/10316/114906 | ISSN: | 1573-9538 1573-9546 |
DOI: | 10.1007/s11302-023-09922-5 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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The-striatum-drives-the-ergogenic-effects-of-caffeinePurinergic-Signalling.pdf | 2.8 MB | Adobe PDF | Ver/Abrir |
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