Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/114906
Title: The striatum drives the ergogenic effects of caffeine
Authors: de Bem Alves, Ana Cristina
Speck, Ana Elisa 
Farias, Hémelin Resende
Martins, Leo Meira
Dos Santos, Naiara Souza
Pannata, Gabriela
Tavares, Ana Paula Gomes 
de Oliveira, Jade
Tomé, Ângelo R. 
Cunha, Rodrigo A. 
Aguiar, Aderbal S. 
Keywords: Caffeine; Dopamine; Grip strength; Mitochondria; Neuroplasticity; Striatum
Issue Date: Dec-2023
Publisher: Springer Nature
Project: LCF/PR/HP17/52190001 
POCI-01- 0145-FEDER-03127 
CENTRO-01-0145-FEDER-000008 
info:eu-repo/grantAgreement/UIDB/04539/2020 
CENTRO-01-0246-FEDER-000010 
Serial title, monograph or event: Purinergic Signalling
Volume: 19
Issue: 4
Abstract: Caffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported the ergogenic mechanism of caffeine through neuronal A2AR antagonism in the central nervous system [1]. We now demonstrate that the striatum rules the ergogenic effects of caffeine through neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) and twenty-four C57BL/6J (8-10 weeks, 23.9 ± 0.4 g) adult male mice were studied behaviorly and electrophysiologically using caffeine and energy metabolism was studied in SH-SY5Y cells. Systemic (15 mg/kg, i.p.) or striatal (bilateral, 15 μg) caffeine was psychostimulant in the open field (p < 0.05) and increased grip efficiency (p < 0.05). Caffeine also shifted long-term depression (LTD) to potentiation (LTP) in striatal slices and increased the mitochondrial mass (p < 0.05) and membrane potential (p < 0.05) in SH-SY5Y dopaminergic cells. Our results demonstrate the role of the striatum in the ergogenic effects of caffeine, with changes in neuroplasticity and mitochondrial metabolism.
URI: https://hdl.handle.net/10316/114906
ISSN: 1573-9538
1573-9546
DOI: 10.1007/s11302-023-09922-5
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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