Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/114906
Title: | The striatum drives the ergogenic effects of caffeine | Authors: | de Bem Alves, Ana Cristina Speck, Ana Elisa Farias, Hémelin Resende Martins, Leo Meira Dos Santos, Naiara Souza Pannata, Gabriela Tavares, Ana Paula Gomes de Oliveira, Jade Tomé, Ângelo R. Cunha, Rodrigo A. Aguiar, Aderbal S. |
Keywords: | Caffeine; Dopamine; Grip strength; Mitochondria; Neuroplasticity; Striatum | Issue Date: | Dec-2023 | Publisher: | Springer Nature | Project: | LCF/PR/HP17/52190001 POCI-01- 0145-FEDER-03127 CENTRO-01-0145-FEDER-000008 info:eu-repo/grantAgreement/UIDB/04539/2020 CENTRO-01-0246-FEDER-000010 |
Serial title, monograph or event: | Purinergic Signalling | Volume: | 19 | Issue: | 4 | Abstract: | Caffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported the ergogenic mechanism of caffeine through neuronal A2AR antagonism in the central nervous system [1]. We now demonstrate that the striatum rules the ergogenic effects of caffeine through neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) and twenty-four C57BL/6J (8-10 weeks, 23.9 ± 0.4 g) adult male mice were studied behaviorly and electrophysiologically using caffeine and energy metabolism was studied in SH-SY5Y cells. Systemic (15 mg/kg, i.p.) or striatal (bilateral, 15 μg) caffeine was psychostimulant in the open field (p < 0.05) and increased grip efficiency (p < 0.05). Caffeine also shifted long-term depression (LTD) to potentiation (LTP) in striatal slices and increased the mitochondrial mass (p < 0.05) and membrane potential (p < 0.05) in SH-SY5Y dopaminergic cells. Our results demonstrate the role of the striatum in the ergogenic effects of caffeine, with changes in neuroplasticity and mitochondrial metabolism. | URI: | https://hdl.handle.net/10316/114906 | ISSN: | 1573-9538 1573-9546 |
DOI: | 10.1007/s11302-023-09922-5 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
The-striatum-drives-the-ergogenic-effects-of-caffeinePurinergic-Signalling.pdf | 2.8 MB | Adobe PDF | View/Open |
Page view(s)
70
checked on Oct 2, 2024
Download(s)
10
checked on Oct 2, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License