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https://hdl.handle.net/10316/114897
Title: | Hypothermia Does Not Boost the Neuroprotection Promoted by Umbilical Cord Blood Cells in a Neonatal Hypoxia-Ischemia Rat Model | Authors: | Serrenho, Inês Cardoso, Carla M. Grãos, Mário Dinis, Alexandra Manadas, Bruno Baltazar, Graça |
Keywords: | neonatal hypoxic-ischemic encephalopathy; umbilical cord blood cells; cell therapy; therapeutic hypothermia; neonatal brain injury | Issue Date: | 23-Dec-2022 | Publisher: | MDPI | Project: | POCI- 01–0145-FEDER-029311 POCI-01-0247-FEDER-045311 UIDP/04539/2020 UIDB/04539/2020 LA/P/0058/2020 UID/Multi/00709/2019 POCI-01-0145-FEDER-022122. |
Serial title, monograph or event: | International Journal of Molecular Sciences | Volume: | 24 | Issue: | 1 | Abstract: | Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of death and long-term disability in the perinatal period. Currently, therapeutic hypothermia is the standard of care for this condition with modest efficacy and strict enrollment criteria. Therapy with umbilical cord blood cells (UCBC) has come forward as a strong candidate for the treatment of neonatal HIE, but no preclinical studies have yet compared the action of UCBC combined with hypothermia (HT) with the action of each therapy by itself. Thus, to evaluate the potential of each therapeutic approach, a hypoxic-ischemic brain lesion was induced in postnatal day ten rat pups; two hours later, HT was applied for 4 h; and 24, 48, and 72 h post-injury, UCBC were administered intravenously. The neonatal hypoxic-ischemic injury led to a brain lesion involving about 48% of the left hemisphere that was not improved by HT (36%) or UCBC alone (28%), but only with the combined therapies (25%; p = 0.0294). Moreover, a decrease in glial reactivity and improved functional outcomes were observed in both groups treated with UCBC. Overall, these results support UCBC as a successful therapeutic approach for HIE, even when treatment with therapeutic hypothermia is not possible. | URI: | https://hdl.handle.net/10316/114897 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms24010257 | Rights: | openAccess |
Appears in Collections: | IIIUC - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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