Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/114777
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Diyaolu, Oluwatofunmilayo A. | - |
dc.contributor.author | Preet, Gagan | - |
dc.contributor.author | Fagbemi, Adeshola A. | - |
dc.contributor.author | Annang, Frederick | - |
dc.contributor.author | Pérez-Moreno, Guiomar | - |
dc.contributor.author | Bosch-Navarrete, Cristina | - |
dc.contributor.author | Adebisi, Olusoji O. | - |
dc.contributor.author | Oluwabusola, Emmanuel T. | - |
dc.contributor.author | Milne, Bruce F. | - |
dc.contributor.author | Jaspars, Marcel | - |
dc.contributor.author | Ebel, Rainer | - |
dc.date.accessioned | 2024-04-10T08:38:40Z | - |
dc.date.available | 2024-04-10T08:38:40Z | - |
dc.date.issued | 2023-01-06 | - |
dc.identifier.issn | 2079-6382 | - |
dc.identifier.uri | https://hdl.handle.net/10316/114777 | - |
dc.description.abstract | In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | Schlumberger Foundation Faculty for the Future Scholarship Program | pt |
dc.relation | UIDB/04564/2020 | pt |
dc.relation | UIDP/04564/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Aspergillus fumigatus | pt |
dc.subject | OSMAC | pt |
dc.subject | metabolomics | pt |
dc.subject | molecular docking | pt |
dc.subject | antitrypanosomal | pt |
dc.subject | antiplasmodial | pt |
dc.subject | in silico molecular docking | pt |
dc.title | Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria | pt |
dc.type | article | pt |
degois.publication.firstPage | 109 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Antibiotics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/antibiotics12010109 | - |
degois.publication.volume | 12 | pt |
dc.date.embargo | 2023-01-06 | * |
dc.identifier.pmid | 36671310 | - |
uc.date.periodoEmbargo | 0 | pt |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
crisitem.author.orcid | 0000-0002-5522-4808 | - |
Appears in Collections: | FCTUC Física - Artigos em Revistas Internacionais I&D CFis - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Antiparasitic-Activities-of-Compounds-Isolated-from-Aspergillus-fumigatus-Strain-Discovered-in-Northcentral-NigeriaAntibiotics.pdf | 3.69 MB | Adobe PDF | View/Open |
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